Are There Any Negative Side Effects to Taking Collagen?

Are There Any Negative Side Effects to Taking Collagen?

07/26/2025 By Bubs Naturals

Table of Contents

  1. Introduction
  2. What Is Collagen and How Does It Work?
  3. Potential Digestive Side Effects
  4. Sensitivities and Allergic Reactions
  5. Assessing the Risk of Kidney Stones
  6. The Importance of Purity and Heavy Metals
  7. Potential Medication Interactions
  8. Lingering Aftertaste and Sensory Issues
  9. How to Minimize the Risk of Side Effects
  10. The BUBS Standard for Safety
  11. Conclusion
  12. FAQ

Introduction

Many of us have made collagen a staple of our morning routines. You might stir it into your coffee, shake it into a post-workout bottle, or mix it into a bowl of oatmeal. We use it to support our joints, keep our skin resilient, and help our bodies with muscle recovery after a long day on the trail or in the gym. At BUBS Naturals, we believe that understanding what you put into your body is just as important as the workout itself.

When a supplement becomes this popular, it is natural to ask questions. You want to know if there is a catch. While collagen is widely regarded as safe and effective for most people, it is important to look at the potential side effects, however rare they may be. Knowing how your body reacts to different protein sources helps you stay on track with your goals without unnecessary setbacks.

In this guide, we will break down the common and uncommon side effects of collagen. We will look at why some people experience digestive changes, how sourcing affects your results, and what you can do to ensure you are using the cleanest product possible. Our goal is to give you the facts so you can keep moving forward with confidence.

Quick Answer: For most people, collagen is highly safe with very few side effects. The most common issues are mild digestive changes like bloating or a feeling of fullness, which often disappear as the body adjusts. Choosing a high-quality, third-party tested product is the best way to avoid impurities or allergens.

What Is Collagen and How Does It Work?

To understand the side effects, we first need to understand the substance itself. Collagen is the most abundant protein in your body. It acts like the "glue" that holds everything together. It provides structure to your skin, strength to your bones, and elasticity to your tendons and ligaments.

Your body produces its own collagen by breaking down dietary protein into amino acids. However, as we age—starting as early as your mid-20s—this natural production begins to slow down. External factors like sun exposure, smoking, and high-sugar diets can accelerate this decline. This is why many people turn to supplements to fill the gap.

Most supplements use hydrolyzed collagen, also known as collagen peptides. Hydrolysis is a process that breaks the large collagen molecules down into smaller, shorter chains of amino acids. This makes the protein much easier for your body to absorb and use. When you ingest these peptides, they travel through your bloodstream to the areas where they are needed most, such as your skin or joint cartilage.

The Common Types of Collagen

While there are at least 28 known types of collagen, most supplements focus on the first three:

  • Type I: This is found in your skin, hair, nails, and bones. It is the most common type and is excellent for structural support.
  • Type II: This is primarily found in cartilage. People focusing on joint health and mobility often look for this specific type.
  • Type III: This is found in your muscles, organs, and blood vessels. It often works alongside Type I to support skin elasticity and gut health.

Potential Digestive Side Effects

The most frequently reported side effects of collagen involve the digestive system. Because collagen is a dense protein, your gut has to work to process it. For most, this is a non-issue, but some people may notice changes when they first start a routine.

Bloating and Fullness

Some users report a sensation of bloating or feeling "too full" after taking their daily scoop. This often happens because protein is naturally satiating. If you are not used to a high-protein intake, your digestive system may need a few days to adjust to the new amino acid profile.

Heartburn or Acid Reflux

In rare cases, people experience mild heartburn. This is sometimes linked to the acidity of the supplement or the specific additives found in flavored versions. If you experience this, try switching to a pasture-raised, unflavored powder that lacks artificial sweeteners or fillers.

Constipation or Diarrhea

Any significant change in diet can alter your bowel habits. Collagen is high in specific amino acids like glycine and proline. While these are generally great for gut lining repair, a sudden influx can occasionally cause a temporary imbalance in the gut. Starting with a smaller dose and gradually working up to a full serving can help your system adapt.

Key Takeaway: Digestive side effects from collagen are usually mild and temporary. They are often a sign that the body is adjusting to a new protein source or that the dosage is too high for a beginner.

Sensitivities and Allergic Reactions

Collagen is derived from animal sources, which means those with specific food allergies must be cautious. Most collagen on the market comes from four primary sources: bovine (cow), marine (fish), porcine (pig), or poultry (chicken).

Marine Collagen and Shellfish Allergies

If you have a known allergy to fish or shellfish, you must be extremely careful with marine collagen. While marine collagen is often praised for its high bioavailability, it can trigger severe reactions in sensitive individuals. Always check the label to see exactly where the protein is sourced.

Bovine and Poultry Sensitivities

Bovine collagen, like our BUBS Naturals Collagen Peptides, is generally well-tolerated. However, if you have a specific sensitivity to beef or chicken, you should look for a source that aligns with your dietary needs. Most high-quality bovine collagen is "pasture-raised" and "grass-fed," which reduces the risk of sensitivities associated with grain-fed industrial farming.

Additives and Fillers

Sometimes, the side effect isn't caused by the collagen itself, but by what the manufacturer added to it. Many brands use artificial flavors, "natural" flavors that contain hidden ingredients, or thickeners like gums and carrageenan. These additives are notorious for causing skin rashes, headaches, or upset stomachs. We avoid these entirely, focusing on single-ingredient or very simple formulas to keep the risk of reaction as low as possible.

Assessing the Risk of Kidney Stones

One of the more common concerns regarding collagen is its potential impact on kidney health, specifically the development of kidney stones. This concern stems from an amino acid called hydroxyproline.

When your body metabolizes hydroxyproline, it can be converted into oxalate. High levels of oxalate in the urine are a primary risk factor for calcium oxalate kidney stones. For the average healthy person, the amount of oxalate produced from a standard dose of collagen is not enough to cause concern. However, if you have a history of kidney stones or have been told by a doctor to follow a low-oxalate diet, you should consult your healthcare provider before starting a collagen regimen.

Myth: Taking collagen will definitely cause kidney stones. Fact: While collagen contains hydroxyproline which can turn into oxalate, there is no evidence that standard doses cause stones in healthy individuals. Those with existing kidney issues should simply use caution.

The Importance of Purity and Heavy Metals

Because collagen is sourced from the skin, scales, and bones of animals, the environment in which those animals lived matters immensely. Animals store toxins and heavy metals in their connective tissues. If a company sources its collagen from low-quality, industrial-scale farms or polluted waters, those contaminants can end up in your supplement.

Heavy Metal Contamination

Lead, arsenic, and cadmium are the primary concerns. Long-term exposure to these metals can lead to a variety of negative health outcomes, including fatigue, joint pain, and neurological issues. This is why we emphasize the importance of third-party testing.

Why Third-Party Testing Matters

You should never have to guess what is in your supplement. Look for brands that utilize independent labs to verify their purity. We take this a step further by ensuring our Collagen Peptides are NSF for Sport certified. This certification means the product has been tested for over 280 banned substances and that the contents of the label accurately reflect what is in the jar. It is the gold standard for athletes and anyone who takes their health seriously.

Potential Medication Interactions

While collagen is a food-based supplement, it can still interact with certain medications. Because it is a concentrated protein, it can affect how your body processes and absorbs other substances.

Blood Thinners

Some research suggests that collagen may play a role in the body's natural blood-clotting process. If you are taking prescription blood thinners like Warfarin, there is a theoretical risk that supplemental collagen could interfere with the medication’s effectiveness. While clinical evidence is limited, it is a conversation worth having with your doctor.

Beta-Blockers

High-protein diets can sometimes change the rate at which the body absorbs certain heart medications, such as propranolol. If you are on a strict medication schedule for heart health, consider taking your collagen at a different time of day than your medication to ensure consistent absorption.

Note: Always consult with your healthcare professional before adding a new supplement to your routine if you are taking prescription medications, especially those for chronic conditions like heart disease or blood pressure.

Lingering Aftertaste and Sensory Issues

While not a "medical" side effect, many people struggle with the taste and smell of low-quality collagen. Some marine collagens can have a distinct fishy odor, while some bovine powders have a "gamey" or "earthy" scent that can ruin a cup of coffee.

At BUBS Naturals, we prioritize a clean, neutral profile. Our collagen is designed to dissolve completely in both hot and cold liquids without clumping or leaving a film. If you have tried collagen in the past and stopped because of the taste, it likely wasn't the collagen itself—it was the processing method. High-quality hydrolysis removes the impurities that cause those unpleasant flavors.

Potential Side Effect Frequency Common Cause How to Manage
Bloating Common Fast introduction of protein Start with half a scoop
Bad Aftertaste Occasional Poor processing or low-quality source Switch to unflavored, grass-fed bovine
Allergic Reaction Rare Sourcing (Fish/Shellfish) Check source (Bovine vs. Marine)
Heartburn Rare Additives or high acidity Choose a "no-filler" brand
Heavy Metal Exposure Very Rare (with good brands) Poor sourcing/Unregulated products Look for NSF for Sport or third-party testing

How to Minimize the Risk of Side Effects

You don't have to leave your results to chance. There are practical steps you can take to ensure your experience with collagen is positive and productive.

Start Small

If you are new to protein supplements, don't jump straight into two or three scoops a day. Start with half a serving for the first week. This gives your digestive enzymes time to catch up and prevents the "heavy" feeling in your stomach.

Stay Hydrated

Protein requires water to be processed effectively by the kidneys and digestive tract. If you increase your protein intake through collagen, make sure you are also increasing your water intake. Adding an electrolyte like our Hydrate or Die formula can help ensure that water actually reaches your cells, aiding in overall digestion and recovery.

Check the Label for Fillers

Avoid products that list "sucralose," "aspartame," "maltodextrin," or "artificial flavors." These are the primary culprits for the "mystery" side effects like headaches and bloating. The shorter the ingredient list, the better the product usually is.

Match the Source to Your Diet

If you follow a specific dietary protocol, choose a collagen that fits. Bovine collagen is ideal for those on Paleo or Keto diets. If you are pescatarian, marine collagen is your go-to. By matching the supplement to what your body is already used to, you reduce the likelihood of a negative reaction.

Bottom line: By choosing a clean, single-ingredient product and starting with a conservative dose, you can enjoy the benefits of collagen while minimizing the risk of any negative side effects.

The BUBS Standard for Safety

We didn't start this company just to sell supplements. We started it to honor the legacy of our friend Glen "BUB" Doherty, a Navy SEAL who lived a life of adventure and purpose. That legacy demands that we never cut corners.

When we talk about "no BS," we mean it. Our collagen is sourced from grass-fed, pasture-raised cattle. It is unflavored, odorless, and mixes effortlessly into your life. Most importantly, we put our products through the most rigorous testing available. When you see that NSF for Sport seal on our tub, you know you are getting exactly what you need to perform and nothing you don't.

Our commitment goes beyond the ingredients. We follow the 10% Rule: we donate 10% of all profits to veteran-focused charities. This mission-driven approach ensures that every scoop you take helps someone else, too. We believe that wellness is a collective effort, and we are proud to provide the fuel for your journey.

Conclusion

Collagen is a powerful tool for anyone looking to support their joints, skin, and overall recovery. While side effects are rare and generally mild, being informed allows you to make the best choices for your specific body and goals. By focusing on high-quality sourcing, avoiding unnecessary additives, and listening to your body’s signals, you can integrate collagen into your routine with peace of mind.

  • Stick to clean, single-ingredient formulas.
  • Verify quality through third-party testing.
  • Start with a lower dose to allow your digestion to adapt.
  • Stay hydrated to support protein metabolism.

Ready to experience the difference that clean, pasture-raised collagen can make? We invite you to try our BUBS Naturals Collagen Peptides. It is the simple, honest support your body deserves.

FAQ

Can collagen cause skin breakouts or acne?

While many people take collagen to improve their skin, a small number of users report breakouts. This is rarely caused by the collagen itself and is more often a reaction to additives, fillers, or a pre-existing sensitivity to the protein source. Switching to a clean, pasture-raised bovine collagen without artificial ingredients usually resolves this issue.

Is it safe to take collagen while pregnant or breastfeeding?

Collagen is generally considered safe as it is a natural protein found in food, but you should always consult your OB-GYN or healthcare provider first. Every pregnancy is different, and your doctor can help you determine if a supplement fits your specific nutritional needs during this time.

Does collagen cause weight gain?

No, collagen itself is unlikely to cause weight gain as it is low in calories and high in protein, which can actually help you feel full longer. However, if you are taking flavored collagen "treats" or gummies that are high in added sugars, those extra calories could contribute to weight changes over time.

How long does it take for collagen side effects to go away?

If you experience mild digestive upset or bloating, these symptoms typically resolve within 3 to 5 days as your body adjusts. If the symptoms persist longer than a week, you may want to reduce your dosage or check if you have a sensitivity to that specific protein source.

*Disclaimer:

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Product results may vary from person to person.

Information provided on this site is solely for informational purposes only. It is not a substitute for professional medical advice. Do not use this information for diagnosing or treating a health problem or disease, or prescribing of any medications or supplements. Only your healthcare provider should diagnose your healthcare problems and prescribe treatment. None of our statements or information, including health claims, articles, advertising or product information have been evaluated or approved by the United States Food and Drug Administration (FDA). The products or ingredients referred to on this site are not intended to diagnose, treat, cure or prevent any disease. Please consult your healthcare provider before starting any supplement, diet or exercise program, before taking any medications or receiving treatment, particularly if you are currently under medical care. Make sure you carefully read all product labeling and packaging prior to use. If you have or suspect you may have a health problem, do not take any supplements without first consulting and obtaining the approval of your healthcare provider.

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